Academic Literature

Postorgasmic-Illness-Syndrome Academic Literature

This page features a growing collection of research articles, case reports, and reviews on postorgasmic-illness-syndrome (POIS) – ideal for patients, clinicians, and researchers alike.

Welcome to the POIS-Network Literature Hub!

If you’re looking for scientific studies, clinical papers, and medical literature on postorgasmic-illness-syndrome (POIS), you’ve found the right place. Since the first scientific study in 2002, a number of specialist articles about postorgasmic-illness-syndrome have been published. This page features a growing collection of research articles, case reports, and reviews – ideal for patients, clinicians, and researchers alike. Please note: These are essentially case studies with very few test subjects. A large-scale study is still lacking.

If you’ve come across a POIS-related paper that’s not listed here, let us know!

E-mail it to us directly at contact@pois-network.com

We regularly update this section as new research emerges.

Postorgasmic illness syndrome

The study by Dorofeev & Krasnyak (2025) provides a review of the literature on Post-Orgasmic Illness Syndrome (POIS) and presents a clinical case illustrating the typical flu-like, cognitive, and autonomic symptoms occurring after ejaculation. The authors conclude that POIS is likely polyetiological (including immunological, neuroendocrine, and autonomic mechanisms) and that hormonal factors such as testosterone may play a potential therapeutic role.

Dorofeev S.D., Krasnyak S.S. Postorgasmic illness syndrome. Experimental and Clinical Urology 2025;18(3):98-107

Treatments for postorgasmic illness syndrome: a systematic review

Sarah Ponce, Meghana Chapalamadugu, Samantha Levine, Cameron Stokes, Karla Radillo, Olivia Johnson, Isaac Bronson, Rachel S Rubin, Treatments for postorgasmic illness syndrome: a systematic review, The Journal of Sexual Medicine, Volume 22, Issue 7, July 2025, Pages 1236–1243

A Role for IgE in Post-Orgasmic Illness Syndrome: Successful Omalizumab Treatment in Absence of Positive Skin Test to Self Semen

Gourgy Hacohen O, Abo-Helo N, Cohen S. A Role for IgE in Post-Orgasmic Illness Syndrome: Successful Omalizumab Treatment in Absence of Positive Skin Test to Self Semen. Am J Case Rep. 2025 Feb

An International Prospective Registry of People with Postorgasmic Illness Syndrome

Paulsen O, Ikedionwu I, Banton J, Sun J, Bronson I, Raheem O, et al. PD28-10 AN INTERNATIONAL PROSPECTIVE REGISTRY OF PEOPLE WITH POSTORGASMIC ILLNESS SYNDROME. Journal of Urology [Internet]. 2024 May 1 [cited 2025 Jan 15];211(5S):e616.

Post-Orgasmic Illness Syndrome in Men: A Literature Review of a Challenging Condition

Lima, V.F.N., Lins, D.J.A.V. & Lima, T.F.N. Post-Orgasmic Illness Syndrome in Men: A Literature Review of a Challenging Condition. Curr Sex Health Rep 16, 230–236 (2024).

Post-orgasmic Illness Syndrome: A Case Report

Alanazi F K, Sawma A, Harisi M, et al. (June 01, 2024) Post-orgasmic Illness Syndrome: A Case Report. Cureus 16(6)

Postorgasmic illness syndrome: one or several entities? A retrospective cohort study.

Chea M, Teng M, Chesnel C, Lagnau P, Amarenco G, Hentzen C. Postorgasmic illness syndrome: one or several entities? A retrospective cohort study. J Sex Med. 2023 Nov 30;20(12):1407-1413.

Recognition and practice patterns of sexual medicine experts towards postorgasmic illness syndrome.

Duran, M.B., Rubin, R.S., Reisman, Y. et al. Recognition and practice patterns of sexual medicine experts towards postorgasmic illness syndrome. Int J Impot Res (2023).

Post-Orgasmic Illness Syndrome Successfully Treated with Omalizumab: A Case Report.

McLean-Tooke, A., & Klinken, E. (2023). Post-Orgasmic Illness Syndrome Successfully Treated with Omalizumab: A Case Report. Journal of Sex & Marital Therapy, 50(3), 342–345.

Flibanserin for Post-Orgasmic Illness Syndrome: A Case Report

M Padhye, P Trowbridge, D Rubin, (236) Flibanserin for Post-Orgasmic Illness Syndrome: A Case Report, The Journal of Sexual Medicine, Volume 20, Issue Supplement_1, May 2023.

Case series: expanding diagnostic markers in postorgasmic illness syndrome

Leah Rosetti, Amin Kanani, Luke Witherspoon, Ryan Flannigan, Stacy Elliott, Case series: expanding diagnostic markers in postorgasmic illness syndrome, Sexual Medicine, Volume 11, Issue 2, April 2023.

Post orgasmic illness syndrome successfully managed with antihistamine: A case report.

Shanholtzer A, Stephens JR, Lauter C, Peters KM. Post orgasmic illness syndrome successfully managed with antihistamine: A case report. Urol Case Rep. 2022 Aug 18;45.

Postorgasmic Illness Syndrome: An Update.

Zizzo J, F Sávio L, Ramasamy R, F N Lima T. Postorgasmic Illness Syndrome: An Update. Eur Urol Focus. 2023 Jan;9(1):22-24.

Novel treatment for post-orgasmic illness syndrome: a case report and literature review.

Huang TB, Yu JJ, Du YJ, Liu ZY. Novel treatment for post-orgasmic illness syndrome: a case report and literature review. Asian J Androl. 2022 May-Jun;24(3):332-334.

Clinical experience with post-orgasmic illness syndrome (POIS) patients-characteristics and possible treatment modality.

Reisman Y. Clinical experience with post-orgasmic illness syndrome (POIS) patients-characteristics and possible treatment modality. Int J Impot Res. 2021 Jul;33(5):556-562.

Analysis of the Symptomatology, Disease Course, and Treatment of Postorgasmic Illness Syndrome in a Large Sample

Caleb Natale, Andrew Gabrielson, Hoang Minh Tue Nguyen, Brian Dick, Wayne J.G. Hellstrom, Analysis of the Symptomatology, Disease Course, and Treatment of Postorgasmic Illness Syndrome in a Large Sample, The Journal of Sexual Medicine, Volume 17, Issue 11, November 2020, Pages 2229–2235.

Postorgasmic illness syndrome: potential new treatment options for a rare disorder

Pierce, H., Fainberg, J., Gaffney, C., Aboukhashaba, A., Khan, A., & Kashanian, J. (2020). Postorgasmic illness syndrome: potential new treatment options for a rare disorder. Scandinavian Journal of Urology, 54(1), 86–88.

Successful treatment of Post-orgasmic illness syndrome with human chorionic gonadotropin.

Bolanos J, Morgentaler A. Successful treatment of Post-orgasmic illness syndrome with human chorionic gonadotropin. Urol Case Rep. 2019 Nov 22;29:101078.

Post orgasmic illness syndrome: what do we know till now?

Abdessater M, Elias S, Mikhael E, Alhammadi A, Beley S. Post orgasmic illness syndrome: what do we know till now? Basic Clin Androl. 2019 Sep 3;29:13.

First assessment of the validity of the only diagnostic criteria for postorgasmic illness syndrome (POIS).

Strashny, A. First assessment of the validity of the only diagnostic criteria for postorgasmic illness syndrome (POIS). Int J Impot Res 31, 369–373 (2019).

Negative allergy study in a case of postorgasmic illness syndrome (POIS).

Depreux N, Basagaña M, Pascal M. Negative allergy study in a case of postorgasmic illness syndrome (POIS). Rev Int Androl. 2018 Jan-Mar;16(1):42-44.

Post orgasmic illness syndrome (POIS).

Waldinger MD. Post orgasmic illness syndrome (POIS). Transl Androl Urol. 2016 Aug;5(4):602-6.

Postorgasmic Illness Syndrome (POIS) in a Chinese Man: No Proof for IgE‐Mediated Allergy to Semen

Nannan Jiang, Guangpeng Xi, Hongjun Li, Jia Yin, Postorgasmic Illness Syndrome (POIS) in a Chinese Man: No Proof for IgE‐Mediated Allergy to Semen, The Journal of Sexual Medicine, Volume 12, Issue 3, March 2015, Pages 840–845

Hyposensitization Therapy with Autologous Semen in Two Dutch Caucasian Males: Beneficial Effects in Postorgasmic Illness Syndrome (Part 2)

Marcel D. Waldinger, Marcus M.H.M. Meinardi, Dave H. Schweitzer, Hyposensitization Therapy with Autologous Semen in Two Dutch Caucasian Males: Beneficial Effects in Postorgasmic Illness Syndrome (POIS; Part 2), The Journal of Sexual Medicine, Volume 8, Issue 4, April 2011, Pages 1171–1176

Postorgasmic Illness Syndrome (POIS) in 45 Dutch Caucasian Males: Clinical Characteristics and Evidence for an Immunogenic Pathogenesis (Part 1)

Marcel D. Waldinger, Marcus M.H.M. Meinardi, Aeilko H. Zwinderman, Dave H. Schweitzer, Postorgasmic Illness Syndrome (POIS) in 45 Dutch Caucasian Males: Clinical Characteristics and Evidence for an Immunogenic Pathogenesis (Part 1), The Journal of Sexual Medicine, Volume 8, Issue 4, April 2011, Pages 1164–1170.

Postorgasm Illness Syndrome—A Spectrum of Illnesses

Jane Ashby, David Goldmeier, CASE REPORT: Postorgasm Illness Syndrome—A Spectrum of Illnesses, The Journal of Sexual Medicine, Volume 7, Issue 5, May 2010, Pages 1976–1981

Postorgasmic Illness Syndrome: Two Cases.

Waldinger, M. D., & Schweitzer, D. H. (2002). Postorgasmic Illness Syndrome: Two Cases. Journal of Sex & Marital Therapy, 28(3), 251–255.

United Against POIS.

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