Postorgasmic-Illness-Syndrome: Major Study Enters Its Crucial Phase – Recruitment Now Open The largest scientific investigation ever conducted on Postorgasmic-Illness-Syndrome (POIS) is now entering its central phase. After the initial stage examined only healthy men (i.e., without POIS symptoms), the recruitment of the affected group is finally beginning—an essential step toward uncovering the mechanisms behind the […]
Postorgasmic-Illness-Syndrome Interview Pascal is 50 years old, divorced, has two children and lives in Berlin, Germany. He has suffered from postorgasmic-illness-syndrome for 25 years. The illness came creeping into his life. We talk to him about his POIS disorder and the effects it has had on his love life, his family, his work and his
Postorgasmic-Illness-Syndrome POIS in Women: A First-Hand Story from South America Postorgasmic-Illness-Syndrome (POIS) is most often discussed as a condition affecting men. Most published research, case studies, and online discussions focus on male patients and theories related to semen allergy or male hormonal responses. However, this does not mean that women cannot suffer from POIS. Their
Post-Orgasmic Illness Syndrome as a Disability – 2024 Study Postorgasmic-Illness-Syndrome as a Disability? – New Study Highlights Severe Impact A large-scale 2024 study reveals how strongly Post-Orgasmic Illness Syndrome (POIS) can impair work, daily activities, and quality of life – raising the question of whether POIS should be classified as a disability. While previous research
Rare Condition Misdiagnosed as Gastritis A new case report published in MAR Gastroenterology (May 2025) documents the first known patient with postorgasmic-illness-syndrome (POIS) in Libya. The study, titled “From Pleasure to Pain: A Case Report of Post-Orgasmic Illness Syndrome Mimicking Gastritis”, was authored by Ashraf M. Rajab and colleagues. The 50-year-old male patient initially presented
POIS Affects Both Body and Mind A new case report from South Asia sheds light on the often-overlooked psychiatric impact of Postorgasmic-Illness-Syndrome (POIS). The patient not only suffered from physical symptoms such as fatigue and pain but also from severe psychiatric issues including: The distress was so overwhelming that the patient even considered chemical or
POIS-Treatment: Dry Ejaculation as a Radical Therapy Option? Hope or extreme exception? – A case report on the treatment of Postorgasmic-Illness-Syndrome A recently published case report describes the dramatic journey of a POIS patient whose years of suffering ended with a radical surgical procedure. The outcome not only offers a potential clue to the underlying
Systematic Review Highlights Treatment Options for Postorgasmic-Illness-Syndrome Systematic Review of POIS Treatments Published A new systematic review published in The Journal of Sexual Medicine provides the most comprehensive overview to date of treatment options for postorgasmic-illness-syndrome (POIS). Researchers analyzed dozens of publications to evaluate which therapies have been tested and how effective they are for
Postorgasmic-Illness-Syndrome News New Study on the Psychosocial Impact of POIS New research highlights how POIS affects self-esteem and relationships A recent survey of 83 men with Post-Orgasmic Illness Syndrome (POIS) provides the first targeted insights into the psychosocial burden of the condition. The results show that POIS not only causes severe physical symptoms but also
First Large-Scale Research on Postorgasmic-Illness-Syndrome In June 2025, the first large-scale study on postorgasmic-illness-syndrome (POIS) officially launched in the United States. Originally planned for 2020, the project was delayed by five years due to the COVID-19 pandemic. The initial test subject was scheduled for examination on the first day of the lockdown, forcing an indefinite