A newly published case report in The Journal of Sexual Medicine describes two men with postorgasmic-illness-syndrome (POIS) whose symptoms improved significantly after treatment with sertraline. The authors suggest that serotonergic mechanisms may play a role in at least some forms of the condition. Two Patients, Similar Symptoms The report presents two men aged 28 and […]
postorgasmic-illness-syndrome One year POIS-Network Growing demand for information 2025 marked the first full calendar year of activity for POIS-Network. Between January 1 and December 31, the platforms POIS-Network and POIS-Deutschland together reached nearly 5,000 users worldwide, generating approximately 30,000 interactions. For a rare and still largely unknown condition, these figures reflect a sustained global demand
A new study from Portugal (preprint) presents two detailed case reports on Postorgasmic-Illness-Syndrome (POIS), providing important insights into the clinical heterogeneity, therapeutic challenges, and psychosocial burden of the condition. The paper describes two men with POIS who developed not only physical symptoms such as extreme fatigue, muscle-related complaints, and cognitive symptoms after ejaculation, but in
Postorgasmic-Illness-Syndrome: Major Study Enters Its Crucial Phase – Recruitment Now Open The largest scientific investigation ever conducted on Postorgasmic-Illness-Syndrome (POIS) is now entering its central phase. After the initial stage examined only healthy men (i.e., without POIS symptoms), the recruitment of the affected group is finally beginning—an essential step toward uncovering the mechanisms behind the
Postorgasmic-Illness-Syndrome Interview Pascal is 50 years old, divorced, has two children and lives in Berlin, Germany. He has suffered from postorgasmic-illness-syndrome for 25 years. The illness came creeping into his life. We talk to him about his POIS disorder and the effects it has had on his love life, his family, his work and his
Postorgasmic-Illness-Syndrome POIS in Women: A First-Hand Story from South America Postorgasmic-Illness-Syndrome (POIS) is most often discussed as a condition affecting men. Most published research, case studies, and online discussions focus on male patients and theories related to semen allergy or male hormonal responses. However, this does not mean that women cannot suffer from POIS. Their
Post-Orgasmic Illness Syndrome as a Disability – 2024 Study Postorgasmic-Illness-Syndrome as a Disability? – New Study Highlights Severe Impact A large-scale 2024 study reveals how strongly Post-Orgasmic Illness Syndrome (POIS) can impair work, daily activities, and quality of life – raising the question of whether POIS should be classified as a disability. While previous research
Rare Condition Misdiagnosed as Gastritis A new case report published in MAR Gastroenterology (May 2025) documents the first known patient with postorgasmic-illness-syndrome (POIS) in Libya. The study, titled “From Pleasure to Pain: A Case Report of Post-Orgasmic Illness Syndrome Mimicking Gastritis”, was authored by Ashraf M. Rajab and colleagues. The 50-year-old male patient initially presented
POIS Affects Both Body and Mind A new case report from South Asia sheds light on the often-overlooked psychiatric impact of Postorgasmic-Illness-Syndrome (POIS). The patient not only suffered from physical symptoms such as fatigue and pain but also from severe psychiatric issues including: The distress was so overwhelming that the patient even considered chemical or
POIS-Treatment: Dry Ejaculation as a Radical Therapy Option? Hope or extreme exception? – A case report on the treatment of Postorgasmic-Illness-Syndrome A recently published case report describes the dramatic journey of a POIS patient whose years of suffering ended with a radical surgical procedure. The outcome not only offers a potential clue to the underlying