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New Case Reports Highlight Clinical Heterogeneity and Gaps in Care in Postorgasmic-Illness-Syndrome

A new study from Portugal (preprint) presents two detailed case reports on Postorgasmic-Illness-Syndrome (POIS), providing important insights into the clinical heterogeneity, therapeutic challenges, and psychosocial burden of the condition. The paper describes two men with POIS who developed not only physical symptoms such as extreme fatigue, muscle-related complaints, and cognitive symptoms after ejaculation, but in […]

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Major POIS Study Enters Crucial Phase — Recruitment Now Open

Postorgasmic-Illness-Syndrome: Major Study Enters Its Crucial Phase – Recruitment Now Open The largest scientific investigation ever conducted on Postorgasmic-Illness-Syndrome (POIS) is now entering its central phase. After the initial stage examined only healthy men (i.e., without POIS symptoms), the recruitment of the affected group is finally beginning—an essential step toward uncovering the mechanisms behind the

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“POIS is like a curse”: In-depth interview with a POIS-sufferer

Postorgasmic-Illness-Syndrome Interview Pascal is 50 years old, divorced, has two children and lives in Berlin, Germany. He has suffered from postorgasmic-illness-syndrome for 25 years. The illness came creeping into his life. We talk to him about his POIS disorder and the effects it has had on his love life, his family, his work and his

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POIS in Women: A First-Hand Story from South America

Postorgasmic-Illness-Syndrome POIS in Women: A First-Hand Story from South America Postorgasmic-Illness-Syndrome (POIS) is most often discussed as a condition affecting men. Most published research, case studies, and online discussions focus on male patients and theories related to semen allergy or male hormonal responses. However, this does not mean that women cannot suffer from POIS. Their

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Postorgasmic-Illness-Syndrome as a Disability – 2024 Study

Post-Orgasmic Illness Syndrome as a Disability – 2024 Study Postorgasmic-Illness-Syndrome as a Disability? – New Study Highlights Severe Impact A large-scale 2024 study reveals how strongly Post-Orgasmic Illness Syndrome (POIS) can impair work, daily activities, and quality of life – raising the question of whether POIS should be classified as a disability. While previous research

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From Pleasure to Pain: First Case of Postorgasmic-Illness-Syndrome in Libya

Rare Condition Misdiagnosed as Gastritis A new case report published in MAR Gastroenterology (May 2025) documents the first known patient with postorgasmic-illness-syndrome (POIS) in Libya. The study, titled “From Pleasure to Pain: A Case Report of Post-Orgasmic Illness Syndrome Mimicking Gastritis”, was authored by Ashraf M. Rajab and colleagues. The 50-year-old male patient initially presented

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POIS Treatment: Dry Ejaculation as a Radical Therapy Option?

POIS-Treatment: Dry Ejaculation as a Radical Therapy Option? Hope or extreme exception? – A case report on the treatment of Postorgasmic-Illness-Syndrome A recently published case report describes the dramatic journey of a POIS patient whose years of suffering ended with a radical surgical procedure. The outcome not only offers a potential clue to the underlying

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Systematic Review Highlights Treatment Options for Postorgasmic-Illness-Syndrome

Systematic Review Highlights Treatment Options for Postorgasmic-Illness-Syndrome Systematic Review of POIS Treatments Published A new systematic review published in The Journal of Sexual Medicine provides the most comprehensive overview to date of treatment options for postorgasmic-illness-syndrome (POIS). Researchers analyzed dozens of publications to evaluate which therapies have been tested and how effective they are for

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New Study on the Psychosocial Impact of POIS

Postorgasmic-Illness-Syndrome News New Study on the Psychosocial Impact of POIS New research highlights how POIS affects self-esteem and relationships A recent survey of 83 men with Post-Orgasmic Illness Syndrome (POIS) provides the first targeted insights into the psychosocial burden of the condition. The results show that POIS not only causes severe physical symptoms but also

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